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Considering that the pathogenesis of human and animal diseases may be completely different and animal models cannot predict the safety and efficiency of drugs on humans, clinical trials are essential for applying TCM drugs to induce ferroptosis for cancer therapy

Inhibition of TrkA + neurons through stimulation of yellow light (0.1 mWatt/mm 2 , 30 min) completely reversed the increased sensitivity and reflex reactions in both early and late phases of arthritis (n = 8)

Further, it would have been advantageous to include a third ROI as a reference region independent of the auditory system

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Consequently, SSB2 exhibits anti-ferroptosis and anti-neuroinflammatory effects, attenuating the activation of the LPS-induced primary microglial TLR4/NF-B signaling pathway in a GPX4-dependent manner (Wang et al., 2023c)